Has performed Alfredo in La Traviata, Cassio in Otello, Cavaradossi in Tosca, Ducca in Rigoletto, the title role in Don Carlos, Edgardo in Lucia di Lammermoor, Radames in Aida, Rodolfo in La Boheme, Vladimir in Prince Igor, Andrey in Khovanshchina, Enzo in La Gioconda, Manrico in Il Trovatore, and Sergey in Lady Macbeth of Mtzensk with many opera houses such as Minsk Opera House, Manaus Brasil, Budapest National Opera House, Theater Ludwigshafen, Heidelberg Opera House, Solothurn Opera Festival, Klagenfurt Opera House, Latvia National Opera House in Riga, Sassari, Italy, and Lisboa.

Being a soloist-member of Mariinsky Theatre, St. Petersburg, he also performed in many other theatres and festivals in Europe, Asia, and America.

High lights of last seasons include Grigory in Boris Godounov (La Monnaie Brussels), Prokofiev's Sept, ils sont sept (Zaterdag Matinee, Concertgebouw Amsterdam), Andrey in Khovanshchina (cover, Liceu Barcelona), From the Jewish Folks Poetry (Anton Philips Concert Hall, The Hague, Netherlands), Edgardo in Lucia di Lammermoor (Mariinsky Opera Theatre), Andrey in Tchaikovsky's Mazeppa (Russian National Orchestra, Moscow), and Verdi Requiem (Moscow International Performing Arts Centre).

More recently Sergey Drobyshevskiy has performed the title part in Don Carlos (Moscow International Performing Arts Centre), Dvorak's Requiem (Russian National Orchestra), Gritsko in Mussorgsky's Sorochinskaya Yarmarka (Mariinsky Theatre), Hoffmann in Les Contes d'Hoffmann (Russian State Symphony Capella), Edgardo in Lucia di Lammermoor (Mariinsky Opera Theatre), Don José in Carmen (Mariinsky Theatre and Krakow), Opera High Lights' concerts (Royal Flemish Philharmonic Orchestra, Antwerp and Havenkom Festival, Almere, the Netherlands), Radames (cover) in Aida and Cavaradossi in Tosca (both in Stuttgart), and New Year's Opera high Lights concert (Concertgebouw Amsterdam), and Shuisky in Boris Godounov (Liège and Santander).